• Testosterone is inactivated through hydroxylation and conjug

  2019-07-01

  

  Testosterone is inactivated through hydroxylation and conjugation pathways [3], [4]. 6β-Hydroxylation is the main pathway among testosterone hydroxylation processes in the liver microsome. Testosterone 6β-hydroxylation is mainly catalyzed by cytochrome P450 3A (CYP3A) [5], [6], which is expressed in

• Recently pharmacological studies have revealed that natural

  2019-07-01

  

  Recently, pharmacological studies have revealed that natural compounds achieve increasing attention due to its high therapeutic effectiveness and low adverse effect, compared with the chemically synthesized compounds. Emodin is a kind of natural anthraquinone derivative enriched in traditional Chine

• The primary outcome was local recurrence or metastasis

  2019-07-01

  

  The primary outcome was local recurrence or metastasis. The secondary outcome included functional outcome based on Musculoskeletal Tumor Society (MSTS) score. Data for the study were retrieved from hospital records, maintained oncological files, surgical files, and clinical examination at the most r

• Several true lumen re entry devices have been

  2019-07-01

  

  Several true lumen re-entry devices have been introduced into the market, including the Outback catheter, allowing fluoroscopically controlled true arterial lumen re-entry after subintimal guidewire passage. A recent retrospective review reported a successful re-entry rate of 91% in 11 patients with

• Effective medical management of cutaneous metastasis arising

  2019-07-01

  

  Effective medical management of cutaneous Amidepsine A structure arising from internal malignancy is usually difficult. Systemic chemotherapy and local excision or radiation therapy may be considered. As for metastatic ampulla of Vater cancer, the more recent histological differentiation in intesti

• br Conflict of interest statement br

  2019-07-01

  

  Conflict of interest statement Acknowledgments Funded by the Division of Medical Oncology at Princess Margaret Hospital, Toronto, Canada. No pharmaceutical company funding was received. The authors acknowledge the roles of Esther Lee and Tazmin Usmani in trial coordination and Dr. Ranjeeta Mal

• br Discussion The cardiac manifestations of organophosphorus

  2019-07-01

  

  Discussion The cardiac manifestations of organophosphorus poisoning are well known, involving various electrocardiographic abnormalities that may range from sinus tachycardia to ST elevation. Such most common abnormalities are sinus bradycardia, prolonged QT interval, and ST elevation [2–4]. Most

• Changing the pacemaker mode to VDD is a good approach

  2019-07-01

  

  Changing the pacemaker mode to VDD is a good approach in cases of normal sinus node function and loss of atrial lead capture, especially if atrial sensing is stable. In this case, Short AV delay is a good way to reduce the risk of R on T phenomenon which is theoretically possible if a ventricular ec

• br Conclusion Elevated levels of the myocardial damage marke

  2019-07-01

  

  Conclusion Elevated levels of the myocardial damage markers c-TNT and H-FABP were not found after ≤10J-DT (9J or 10J) in patients who underwent device implantation. Our findings confirm that minimally-invasive DT has an acceptable success rate. To prevent unnecessary myocardium damage, ≤10J-DT ma

• During the ACh provocation test our patient did not complain

  2019-07-01

  

  During the ACh provocation test, our patient did not complain of chest pain, ECG showed no discernible ST-T changes, and CAG demonstrated no spastic findings. These indicate that ACh evoked the J wave by its direct pharmacological actions in this case. J waves are currently recognized as a surface E

• En toda su trayectoria una constante

  2019-07-01

  

  En toda su trayectoria una constante que ha sido reconocida por la comunidad académica y por él mismo, en diversas ocasiones, fue la de “bautizar los nuevos animales”, la de crear conceptos para fenómenos nuevos que consideró específicos, en el marco de la búsqueda en su última etapa de una teoría d

• br Introduction Aplastic anemia AA

  2019-07-01

  

  Introduction Aplastic anemia (AA) is a rare disease characterized by pancytopenia and a hypocellular bone marrow. Specific cytogenetic abnormalities, monosomy 7 and trisomy 8, are frequently associated with clonal evolution [1]. Clonal cytogenetic abnormalities also may be present with hypocellul

• In most patients with MCL multi

  2019-07-01

  

  In most patients with MCL, multi-organ involvement with organ damage is seen [2–5,10]. In most cases, the BM is the primary site of disease evolution [13]. However, only a smaller subset of patients with MCL present with circulating MC, and only very few cases present with rapidly increasing numbers

• While this report demonstrates that CMA with SNP arrays is

  2019-07-01

  

  While this report demonstrates that CMA with SNP arrays is useful for the analysis of genomic imbalances in the peripheral blood of patients with suspected MDS, this technique is not readily available at many medical centers and many institutions perform fluorescence in situ hybridization to detect

• One study reported the role of the Purkinje

  2019-06-29

  

  One study reported the role of the Purkinje system with respect to the relationship between the septum and HCM-related VT. Santangeli et al. reported that patients with HCM also often have His-Purkinje conduction-related septal abnormalities, and bundle branch block often develops as part of the nat

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