• br GnRH receptor expression is altered within GnRH

  2022-02-17

  

  GnRH receptor expression is altered within GnRH neuronal cells Kisspeptin failed to stimulate GnRH expression in our line of GT1-7 cells. Instead, we have found that kisspeptin increased the expression of the GnRH receptor in these GDC-0349 receptor (Sukhbaatar et al., 2013). Based on the result

• Obeticholic Acid br Experimental procedures br Results br Di

  2022-02-17

  

  Experimental procedures Results Discussion Although the presence and localization of the GlyR subunits have been determined in the adult retina, the proportion of each GlyR subunit has not been assessed in the adult or in the developing retina. In the present study, we carried out the absol

• Calmidazolium chloride br Materials and methods br Results

  2022-02-17

  

  Materials and methods Results Discussion Neurotransmitter uptake is one of the most important aspects of synaptic transmission, it fact, the existence of a specific uptake system is one of the requisites that any neuroactive substance has to cover to be considered a neurotransmitter. It has

• Finally it is possible that the increase

  2022-02-17

  

  Finally, it is possible that the increase in the number of EAAT-3-labelled cells in the DG at PD 60, when compared with the control and experimental animals at PD 14, is associated with natural changes in the number of neurons present during the postnatal development of the hippocampus (41, 42) and,

• ICH induced striatal lesion produced a reduction of EAAT exp

  2022-02-17

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino Silvestrol transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia

• Introduction Human pathogenic Leishmania protozoa comprise d

  2022-02-17

  

  Introduction Human pathogenic Leishmania protozoa comprise 20 different species that are distributed throughout the world and cause the disease leishmaniasis [1]. Transmission primarily occurs through the bite of a female sand fly and clinical manifestations of the disease span from cutaneous lesio

• Introduction Human pathogenic Leishmania protozoa comprise d

  2022-02-17

  

  Introduction Human pathogenic Leishmania protozoa comprise 20 different species that are distributed throughout the world and cause the disease leishmaniasis [1]. Transmission primarily occurs through the bite of a female sand fly and clinical manifestations of the disease span from cutaneous lesio

• These various observations indicate that GIP plays an

  2022-02-17

  

  These various observations indicate that GIP plays an important role in the normal compensatory islet response to high fat feeding. This likely reflects the loss of the combined actions of intra-islet GIP together with intestinally-derived GIP entering the islet vasculature following secretion from

• The caseins are a family of

  2022-02-17

  

  The caseins are a family of milk phosphoproteins whose biological function is to provide supersaturating concentrations of calcium, phosphates, and essential c75 to the neonate (Vonderhaar and Ziska, 1989). α- and β-caseins, the most abundant of the milk caseins, are described as calcium sensitive

• As many of the above studies highlight several

  2022-02-17

  

  As many of the above studies highlight, several decades of research on Cx43 has revealed that many of these functional roles are attributed to the C-terminal domain (CT) of this protein which cannot be explained by the formation and existence of intercellular channels. Recent findings on the existen

• Comparison of dlGALRs deduced amino

  2022-02-17

  

  Comparison of dlGALRs deduced amino MLN4924 sequences with that of human GALRs demonstrate that the GALR1 ortholog sequences have diverged less than those of GALR2. Since often duplicate genes undergo divergent evolution through sub-functionalization, loss or gain of new functions (Prince and Picke

• The overall decrease in consummatory

  2022-02-17

  

  The overall decrease in consummatory drive seen in rodents treated with naltrexone in previous studies is in accordance with the effects seen with mice treated with SNAP 37889 in this study. While it may seem inappropriate to use a broad-acting drug like SNAP 37889 that suppresses overall consummato

• Hypocotyl development is a crucial phase of

  2022-02-17

  

  Hypocotyl development is a crucial phase of early vegetative growth that influences seedling vigor contributing to fitness and productivity of a plant system (Stinchcombe and Schmitt, 2006; Luo et al., 2017). The development of a hypocotyl is characterized by an initial slow growth phase followed by

• br Materials and methods br Results

  2022-02-17

  

  Materials and methods Results and discussion Conclusions Acknowledgements This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684), and also by t

• The effect of GC on

  2022-02-17

  

  The effect of GC on Fgf21 was not directly dependent on ileal Fgf15 because basal Fgf21 sorafenib tosylate was similar in Fgf15+/+ and Fgf15−/− mice. Moreover, GC treatment induced similar Fgf21 up-regulation in both strains. Fxr activation has been reported to increase Fgf21 expression and secreti

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