• The HIF complex was initially identified as an important com

  2022-02-15

  

  The HIF complex was initially identified as an important component of the cell machinery involved in the response and Radicicol to hypoxia (Semenza, 2001). Further studies have shown that HIF can also modulate whole-body energy homeostasis by controlling hypothalamic neurons (Varela et al., 2017, Zh

• In addition to SAHA SBHA also

  2022-02-15

  

  In addition to SAHA, SBHA also showed a strong rescue effect. SAHA is a general inhibitor of HDAC function (Finnin et al., 1999, Kim and Bae, 2011), while SBHA is more specific, and has been shown to inhibit HDAC1 and HDAC3 (Richon et al., 1998). The relative level of suppression was similar in Kis

• br Conclusion The addition of cellulose to natural substrate

  2022-02-15

  

  Conclusion The addition of Sulfo-NHS-Biotin to natural substrate increases the number of H-bonds which indicates an increase in the stability of the docking systems. The investigated compounds are more stable than natural substrate in docking systems, where the natural substrate has two H-bonds

• Bioinformatic analysis revealed a putative coiled coil SLD

  2022-02-15

  

  Bioinformatic analysis revealed a putative coiled-coil SLD within CT229 which we show to be essential for intracellular replication and recruitment of Rab GTPases to the inclusion. Mutation of a single amino PR619 residue in the SLD domain (CT229L120D) significantly reduced Rab binding and recruitm

• GSTP is a class Glutathione S transferase

  2022-02-15

  

  GSTP1 is a π-class Glutathione S-transferase (GST-π) enzyme involved in tumor suppression by protecting BX795 against genomic damage mediated by various oxidants. Although the loss of GSTP1 function by hypermethylation has been reported as a common epigenetic alteration in prostate carcinogenesis (

• br Results and discussion GSTP is a Phase II cytoprotective

  2022-02-15

  

  Results and discussion GSTP1 is a Phase II cytoprotective and detoxifying enzyme. Due to its role in the detoxification of numerous endogenous and exogenous chemical agents (with electrophilic functional groups), individuals with Ile105Val mutation in this gene show enhanced risk of atopic disord

• Thieno-GTP synthesis However although lactic acid suppresses

  2022-02-14

  

  However, although lactic Thieno-GTP synthesis suppresses the activation of effector , rendering them unable to buffer intracellular acidity [32], other T cell subpopulations such as regulatory T cells (Tregs) exhibit metabolic adaptations in low-glucose, high-lactate environments. In particular, Tr

• Since KYNA concentrations are increased by

  2022-02-14

  

  Since KYNA concentrations are increased by aerobic exercise training, we have investigated if it plays a role in peripheral tissue metabolism. Here we show that KYNA regulates adipose tissue energy homeostasis through activation of Gpr35. Activation of this network stimulates the expression of lipid

• Transcriptional translational modulators The discovery that

  2022-02-14

  

  Transcriptional/translational modulators. The discovery that β-lactam antibiotics like ceftriaxone enhance the in vivo expression of EAAT2/GLT-1 [31] has pioneered a completely new approach to EAAT modulation, with several additional EAAT activators following in its trail (Figure 2b) [32, 33, 34•, 3

• The association between mental disorders and smoking was

  2022-02-14

  

  The association between mental disorders and smoking was firmly established, and their inter-relationship was due to the reciprocal causal effects (Tjora et al., 2014). Previous research found that negative affect and the urge to smoke as well as the urge to smoke and nicotine dependence had signifi

• dihydrofolate reductase inhibitor GKRP binds to the inactive

  2022-02-14

  

  GKRP binds to the inactive, super-open conformation of GCK, acting as a competitive inhibitor of glucose association with the enzyme (Fig. 3) [45]. Upon formation of the inhibitory complex with GKRP, GCK is sequestered into the hepatocyte nucleus [48]. The detailed mechanism by which GKRP mediates t

• LbGlcK crystallized as a ligandless dimer in the asymmetric

  2022-02-14

  

  LbGlcK crystallized as a ligandless dimer in the asymmetric unit of space group P21 (Fig. 1a) with two identical subunits stabilized by a large contact surface area of 2295 Å2 (13% of the total surface area) as determined by the Protein Interfaces, Surfaces, and Assemblies (PISA) server [18]. Each m

• Analysis of genomic neighborhoods has

  2022-02-14

  

  Analysis of genomic neighborhoods has helped resolve questions concerning the orthology of receptors for peptides similar to glucagon (Ng et al., 2010, Irwin and Prentice, 2011, Wang et al., 2012, Hwang et al., 2013). Using a diverse array of species with available genome sequence (see Fig. 4) the g

• GLI proteins activate or repress transcription

  2022-02-14

  

  GLI proteins activate or repress transcription of their target genes by binding to a similar sequence motif within a cis-regulatory module (CRM) (Hallikas and Taipale, 2006, Peterson et al., 2012). Transcriptional responses to the HH pathway can be elicited either by de-repression of GLI-R or in oth

• The overall very satisfactory potency profile of compounds a

  2022-02-14

  

  The overall very satisfactory potency profile of compounds 7a–l suggests that 1,3,4-thiadiazole-2-carboxamide moiety was a suitable periphery group to add to the 3-phenylpropanoic Compstatin core in order to improve affinity to FFA1. The agonist activity in this series appears to be particularly se

15743 records 498/1050 page Previous Next First page 上5页 496497498499500 下5页 Last page