• As recently reviewed a picture is emerging where metabolites

  2021-11-15

  

  As recently reviewed, a picture is emerging where metabolites through GPCR sensors act as important autocrine and paracrine regulators of basic metabolic mechanisms (Husted et al., 2017). The concept of 20-HETE acting through FFAR1 as an autocrine amplifier of GDIS on β p53 tumor suppressor togethe

• Anhydrotetracycline hydrochloride br Conclusion In conclusio

  2021-11-15

  

  Conclusion In conclusion, rats in this model of HELLP syndrome demonstrated increased placental and circulating FasL and increased placental Fas when compared to NP rats. Administration of an ETA receptor antagonist to HELLP rats tended to decrease circulating FasL and placental Fas, while not af

• Naphthoquine phosphate sale HIV incidence is often determine

  2021-11-15

  

  HIV incidence is often determined by following cohorts of HIV-uninfected individuals and quantifying the rate of new HIV infections. HIV incidence can also be estimated using a cross-sectional study design, using laboratory assays to identify individuals who are likely to have recent HIV infection.

• br Introduction Regulation of transcription

  2021-11-15

  

  Introduction Regulation of transcription is a critical event of the embryonic development and epigenetic mechanisms such as histone modifications and DNA methylation appear important in mediating temporal changes, and differences among cells/tissues, of temporary stabilized transcriptomes (Mas et

• br Histamine H R The

  2021-11-15

  

  Histamine H4R The cloning of the H3R (Lovenberg et al., 1999) provided a template for the search of other Caspase-8, human recombinant protein receptors, and resulted in the most recent discovery of histamine H4R. This concluded with six independent groups that have reported the cloning of the H4

• br Retrieval requires histamine H receptors

  2021-11-15

  

  Retrieval requires histamine H1 receptors in dorsal hippocampus Retrieval is a dynamic process that requires neurotransmitter regulation (Barros et al., 2000, Barros et al., 2001). Recently, histamine, and histaminergic transmission has entered the list of putative neurotransmitter modulators of

• Unfortunately the approved drugs suffer from

  2021-11-15

  

  Unfortunately, the approved drugs suffer from failure in many cases [5,6]. Several mutations occur in the binding site of NS3/4A protease, which affect drug binding and cause drug resistance [13]. It is a big challenge and needs more efforts to be done. This is the reason why research is still conce

• br Pathophysiology of glaucoma Glaucoma is a group of optic

  2021-11-15

  

  Pathophysiology of glaucoma Glaucoma is a group of optic neuropathies defined by progressive degeneration of RGCs and their PFTα in the optic nerve, which leads to irreversible loss of vision [3,8,9]. RGC degeneration is often significantly advanced before changes in visual acuity and evidence of

• BML-277 Historically pharmacological investigations have bee

  2021-11-12

  

  Historically, pharmacological investigations have been carried out by first identifying a biological response to a ligand, and then subsequently using that ligand to identify the receptor(s) responsible for the response (Wilson et al., 1998). However, this approach needed revision with the discovery

• In this study we further expanded the antitumor

  2021-11-12

  

  In this study, we further expanded the antitumor bioactivity, with the BALB/c S-180 tumor model, which is long-established due to its highly aggressive in all strains of laboratory mice and rats (Cui et al., 2003). We investigated the tumor-regressing ability of β-glucan by different modes of admini

• br Materials and methods br Results br Discussion

  2021-11-12

  

  Materials and methods Results Discussion Neurotransmitter uptake is one of the most important aspects of synaptic transmission, it fact, the existence of a specific uptake system is one of the requisites that any neuroactive substance has to cover to be considered a neurotransmitter. It has

• br Results and discussion A diverse set of

  2021-11-12

  

  Results and discussion A diverse set of compounds were synthesized to improve the PK and physicochemical properties of 2. Compounds' agonist effects on hGPR40 were assessed by calcium mobilization assay using hGPR40-HEK293 cell line which stably expressed human GPR40. Preliminary explorations fo

• Ability of D Ala GIP to attenuate the neurobehavioral sequel

  2021-11-12

  

  Ability of D-Ala2GIP to attenuate the neurobehavioral sequelae in QA-induced Huntington's disease model by reduction in lipid peroxidation, restoration of endogenous antioxidants and decreased striatal monoamine levels is of potential interest. Considerable preclinical evidence now exists of the pot

• br Mechanisms of action Ghrelin is

  2021-11-12

  

  Mechanisms of action Ghrelin is a 28-amino epz peptide hormone primarily produced in the oxyntic mucosa of stomach, but also in other gastrointestinal tissues [7] (Fig. 1). It acts as the endogenous ligand for the ghrelin receptor [GHS-R1a] and causes the release of growth hormone from the pitui

• The first FPR ligand described is

  2021-11-12

  

  The first FPR1 ligand described is the fMLF peptide, which binds with high affinity (in the nM range) to and activates FPR1. Formylated peptides derived from Listeria monocytogenes also selectively activate FPR1 [10] (Table 1). Formylation of peptides also occurs in mitochondria. Thus, the release o

16078 records 576/1072 page Previous Next First page 上5页 576577578579580 下5页 Last page