• Although many of the hepatic

  2020-07-29

  

  Although many of the hepatic responses observed on the first day of recovery attenuated over the course of the recovery period, minimal-to-mild centrilobular hepatocellular hypertrophy tended to persist. Mean absolute and relative liver weights had returned to control levels after 28 days of recover

• ICT is a product of icariin via the metabolism

  2020-07-29

  

  ICT is a product of icariin via the metabolism of intestinal bacteria with an estrogen-like chemical structure where the C-3 and C-7 are hydroxylated [29], and exhibits estrogen-like activities [26], [14]. Therefore, we hypothesized that ICT had estrogen-like effects to modulate the differentiation

• Although PQQ has nutritional importance and pharmacological

  2020-07-29

  

  Although PQQ has nutritional importance and pharmacological effects in higher organisms, including humans [15], until recently, there was no clear evidence for the use of PQQ as a co-factor in a eukaryotic enzyme. This review presents a novel eukaryotic PQQ-dependent quinohemoprotein recently discov

• br Conflict of interest br Acknowledgements

  2020-07-29

  

  Conflict of interest Acknowledgements This work is funded by the National Institutes of HealthR01-GM069909 (YMC), Welch Foundation (I-1532; YMC), Leukemia and Lymphoma Society Scholar award (YMC), CPRIT (RP120352; YMC) and the UT Southwestern Endowed Scholars Program (YMC). We thank Q. Sun and

• Imaging of primary Tfh cells

  2020-07-28

  

  Imaging of primary Tfh cells at the peak of the GC response revealed clear spatial segregation in the FM and GC compartments. This confinement was confirmed by TPP and discontinuous cell tracking 24 hr later, which showed retention of the majority of photoconverted GC Tfh cells in the original GC an

• br Chemistry The synthetic route of A

  2020-07-28

  

  Chemistry The synthetic route of A, B, and C is depicted in Scheme 1. Substituted-amidine and 2-(ethoxymethylene)malononitrile as starting material was used to prepare 4-amino-2-substitutedpyrimidine-5-carbaldehyde 2 according to the literature method.2 is the key intermediate for the preparatio

• In astrocytes mitogen activated protein kinases MAPKs are

  2020-07-28

  

  In astrocytes, mitogen-activated protein kinases (MAPKs) are activated after OGD-induced ischemic injury (Yung and Tolkovsky, 2003, Niu et al., 2009) and they regulate induction of AQP expression (Arima et al., 2003, McCoy and Sontheimer, 2010). It is well known that MAPKs, including extracellular s

• It is important to note that CRF may be

  2020-07-28

  

  It is important to note that CRF1 may be activated during acute stress and early phases of anxiety disorders (Coric et al., 2010, Ising et al., 2007), as well the administration of Astressin 2B into the lateral septum did not have an effect on anxiety-like behavior in low-stress conditions but had a

• The innovation of new compounds and new mechanisms

  2020-07-28

  

  The innovation of new compounds and new mechanisms for studying the role of highly active antiviral compounds has become the focus of research attention (Gao et al., 2012; Li et al., 2007; Long et al., 2015; Chen et al., 2016; Zhang et al., 2016; Xie et al., 2018; Wu et al., 2017; Zhang et al., 201

• br Introduction Esophageal squamous cell carcinoma ESCC

  2020-07-27

  

  Introduction Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer in East Asia and is a leading cause of cancer-related death worldwide.1, 2 Surgery is widely used for treatment in localized disease, where it can provide definitive management and potential cure. Tre

• To date six different CXC

  2020-07-27

  

  To date, six different CXC clades have been found in teleost fish: CXCa, CXCb, CXCc, CXCd, CXCL12 and CXCL14 (Huising et al., 2003, 2004). However, not all fish contain these six clades of CXC chemokine genes. For example, CXC chemokines belonging to the CXCc clade are only found in carp (Cyprinus c

• We propose two hypotheses to interpret our findings

  2020-07-27

  

  We propose two hypotheses to interpret our findings. The first, ELR (+) CXC chemokines stimulate both CXCR-1 and CXCR-2 chemokine receptor while activating neutrophils; however CXCR-1 chemokine receptor seems to play more active role in the process of neutrophil migration as shown in previous studie

• br Results br Discussion Efficient nuclear

  2020-07-27

  

  Results Discussion Efficient nuclear export requires CRM1 to recognize a wide diversity of cargos with high affinity in the nucleus while averting adverse binding events in the cytosol. Previous studies identified two structural elements of CRM1 as critical for maintaining the low-affinity cyt

• Lung fibroblasts as the predominant effector cells play

  2020-07-27

  

  Lung fibroblasts, as the predominant INDY cells, play a vital role in the development of pulmonary fibrosis [16]. In response to various stimuli, quiescent lung fibroblasts are activated and trans-differentiate into myofibroblasts, producing large amounts of ECM, pro-inflammation cytokines, and pro

• ATRX belongs to the switch sucrose non fermenting SWI SNF

  2020-07-25

  

  ATRX belongs to the switch/sucrose non-fermenting (SWI/SNF) chromatin remodeling family, mutations in which cause syndromal mental retardation and downregulation of α-globin expression (Gibbons et al., 1995). Most of these mutations are located in two highly conserved regions of the ATRX protein: a

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