• ALK fusion positive NSCLC is clinically actionable because i

  2024-08-30

  

  ALK fusion-positive NSCLC is clinically actionable because it can be targeted by several FDA-approved drugs, including the first generation TKI crizotinib, which is a dual inhibitor to MET and ALK [15], and the second generation inhibitors, alectinib and ceritinib, both of which are highly-selective

• br Introduction Psychostimulant abuse and addiction remain a

  2024-08-30

  

  Introduction Psychostimulant abuse and addiction remain a societal problem in the United States. The latest statistics from the National Survey on Drug Use and Health indicate that slightly less than one million people over the age of 12 report having a cocaine use disorder (NSDUH, 2016). Additio

• Preclinical models indicate roles for adiponectin in

  2024-08-30

  

  Preclinical models indicate roles for adiponectin in the maintenance of hepatic lipid metabolism. Adiponectin overexpression prevents accumulation of triglycerides or the deleterious lipid metabolites diacylglycerols or ceramides [5,8]. Direct manipulation of adiponectin expression demonstrates a po

• In addition to the above mentioned

  2024-08-30

  

  In addition to the above-mentioned synaptic mechanisms, the serotonergic system also has a critical role in the antidepressant effects of mGlu2/3 receptor antagonists. Indeed, we previously reported that mGlu2/3 receptor antagonists increased the firing rate of serotonin neurons in the dorsal raphe

• br Introduction Adenosine deaminase ADA which can catalyze t

  2024-08-30

  

  Introduction Adenosine deaminase (ADA), which can catalyze the conversion of AD to inosine by removing an amino group, is a key hydrolytic enzyme of purine metabolism (Conway and Cooke, 1939), and plays an important role in an amount of diseases. For example, an increase of ADA activity in serum

• Balaglitazone Serum soluble sCD is a

  2024-08-30

  

  Serum soluble sCD21 is a shedding product from the ectodomain of membrane CD21 after B cell activation (Masilamani et al., 2003, Masilamani et al., 2004a, Masilamani et al., 2004b, Grottenthaler et al., 2006, Hoefer et al., 2008), which resembles the ligand-binding capacity of intact CD21 (Wu et al.

• β-Sitosterol br Acknowledgments br Introduction Hypospadias

  2024-08-30

  

  Acknowledgments Introduction Hypospadias is a common congenital malformation in males, in which the urethral orifice is found on the ventral side of the penis as a result of incomplete fusion of urethral folds. The mean prevalence in per 10,000 live births from 1910 to 2013 were: Europe 19.9,

• br Materials and methods br Results br Discussion br

  2024-08-30

  

  Materials and methods Results Discussion Author contributions JH purified protein, performed vanadate inhibition experiments, crystallized, collected data, determined and refined the ATX-VO5 structure, analysed all the structures, prepared the displayed items and supervised ALHE; WJK con

• br Conclusions In the current study

  2024-08-29

  

  Conclusions In the current study, we found that the exposure of maduramicin to chicken myocardial ck2 inhibitor results in cellular damage and even death via the induction of apoptosis. Maduramicin upregulated the expression of apoptotic genes and activated caspase cascades, which were accompani

• In Pham et al employed the microsphere based technology

  2024-08-29

  

  In 2014, Pham et al. [22] employed the microsphere-based technology to create a Luminex probe-based assay for the rapid identification of single nucleotide polymorphisms that are known to confer resistance to one or more echinocandins in C. glabrata. The targets for the FKS probes were generated usi

• Plant pathogenic fungi have caused a lot of economic losses

  2024-08-29

  

  Plant pathogenic fungi have caused a lot of economic losses to agricultural production worldwide every year. It is necessary to develop an bio-sourced antifungal agent for agricultural use. Many researches have shown that the antifungal activity of quaternized chitosan derivatives is mainly affected

• br Brain Angiotensin II receptors The information above

  2024-08-29

  

  Brain Angiotensin II receptors The information above leaves Angiotensin II receptors as the only RAAS components for which localization, regulation of expression and function in the Caspase-6, human recombinant protein has been convincingly demonstrated, with the use of quantitative film and emu

• br Introduction Metabolic cues are

  2024-08-29

  

  Introduction Metabolic cues are crucial inputs in dictating acute responses through governing cellular signaling pathways as well as in shaping up long-term transcriptional and epigenetic profiles to control chronic cellular responses (Lu and Thompson, 2012). It has been well documented that meta

• br Conclusions Triptans are HT B D

  2024-08-28

  

  Conclusions Triptans are 5-HT1B/1D/(1F) receptors agonists and are considered as the gold standard for acute migraine treatment that have been proven effective. Unfortunately, they are contraindicated in patients with cardiovascular diseases due to their vasoconstrictor (side) effects (MaassenVan

• br Autophagy inducers Macroautophagy is often seen as a

  2024-08-28

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of Phosphatase Inhibitor Cocktail 1 (100X in DMSO) and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective s

16031 records 91/1069 page Previous Next First page 上5页 9192939495 下5页 Last page